The new restaurant will open at the DoubleTree by Hilton, Bristol South, Cadbury House in Congresbury and will start to welcome guests towards the end of August.
The fiery chef, famed for his no-nonsense approach and Michelin-star food, has confirmed that his latest eaterie will be at the contemporary venue that has been transformed over the past four years following investment of around £20 million.
The opening of the new restaurant follows meetings with owner Nick Taplin and group general manager Mark Hands who are now getting the new venue ready to open later in the year.
Mark Hands, said:
"We're absolutely thrilled to have someone of Marco's calibre open one of his restaurants at DoubleTree by Hilton, Cadbury House. It clearly demonstrates our commitment to continually bring the best to the venue and we can’t wait for the Autumn.
"Up until now DoubleTree by Hilton, Cadbury House has arguably been regarded as being the best hotel across Bristol and North Somerset. The arrival of Marco will now reinforce this position."
Nick Taplin, said:
"We are very proud to have Marco as a business partner and look forward to working closely with him to make this new restaurant a huge success.
"It again raises the bar in terms of what people can come to expect at restaurants in the region and we look forward to welcoming guests when it opens. It is also great news for the area as a whole and we hope it will attract more people to the region who will see for themselves why the South West is such a great place."
By the age of 33, Marco had become - at the time - the youngest chef to be awarded three Michelin Stars and had working for him Gordon Ramsay and Heston Blumenthal.
"I've visited Doubletree by Hilton, Cadbury House a number of times now and I've been very impressed not only by the venue itself but the vision of Nick and Mark. They have a self belief and determination to bring the very best to guests who stay at the hotel and dine in the restaurant.
"It's going to be a very exciting time and I'm really looking forward to bring my vision of dining out to the South West."
John Hallett managing director of Destination Bristol added:
"This is superb news for the region. Marco Pierre White is without doubt one of the most influential chefs the country has ever produced and to have him open a restaurant in the heart of the region will not only bring more people to the area but really place North Somerset on the map.
"As far as restaurants go this really has to be the one of the best things to have happened across Bristol and the South West for a long time."